Skip to main content

2025 selected projects

Six early-stage projects in advanced therapies have been selected for the first edition of ATMP Catalyst. All of them are based in Catalonia and work at TRL 2–3, aiming to validate their technology and advance in preclinical and regulatory development. Discover them!

THOR

This project is developing a modular universal CAR-T system that combines a second-generation CAR with a bispecific switch, initially targeting glioblastoma. The design enables flexibility in addressing various tumor types without redesigning the CAR structure, offering significant potential for application in oncology and autoimmune diseases.

Subsector: Advanced therapies

Phagocytic Synthetic Cells

Focused on combatting multidrug-resistant respiratory infections in cystic fibrosis patients, this project is developing synthetic cells inspired by natural phagocytosis. These cells engulf and eliminate bacteria directly in the airways without antibiotics, helping prevent resistance and offering a breakthrough for vulnerable patients.

Subsector: Advanced therapies

CARcoma

The CARCOMA project targets metastatic sarcomas with novel CAR-T cells engineered to secrete a mutated Fc TIM3 decoy. This approach addresses an unmet clinical need by enhancing T-cell function and persistence in challenging tumor environments.

Subsector: Advanced therapies

NoctuRNA

This project pioneers’ circular RNA-based therapies to treat currently incurable diseases. These innovative molecules target critical RNA secondary structures involved in infectious and genetic disorders, opening new therapeutic frontiers.

Subsector: Advanced therapies

Spes Immunotherapies

Spes develops personalized cancer vaccines for patients with acute leukemia. Their patented TCR-based platform designs individualized vaccines that match each patient’s specific genetic mutations, aiming to improve immune responses and prevent relapse. Their first candidate focuses on acute lymphoblastic leukemia (ALL), with plans to expand into other leukemias and solid tumors.

Subsector: Advanced therapies

FORCE

FORCE is developing an ex vivo platform that enhances mitochondrial transfer from healthy donor T cells to patient-derived T cells. This restores mitochondrial function and reduces mutational load, with potential applications in mitochondrial diseases, cancer immunotherapy, and age-related immune decline.

Subsector: Advanced therapies
Sign up for our newsletters

Stay up-to-date on the latest news, events and trends in the BioRegion.